The Flintstones (1960)

S3E3 Barney the Invisible

To help Barney with his relentless hiccups, Fred gives him a taste of an experimental soda he has created. However, the concoction has an unexpected side effect: it makes Barney invisible. As Fred scrambles to cover up this bizarre turn of events, Wilma starts to question her husband's sanity, perplexed by his odd behavior and the peculiar situation unfolding around them.