Totally Spies! (2002)

S4E11 Evil Bouquets Are Sooo Passe…

As men begin to succumb to a mysterious, lethargic sleep, the spies are dispatched to uncover the cause. Their investigation leads them to Violet Vanderfleet, a bitter woman who has unleashed a toxic hybrid flower, known as Viola Vanderfleetus, to eradicate the male population in retaliation for her past heartbreaks. Meanwhile, in a subplot, Sam finds herself attracted to Clover's former boyfriend. The main antagonist is Violet Vanderfleet.